Design, Development and Evaluation of Mucoadhesive Film for Water Insoluble Drug Using Different Plasticizers

Objective: The goal of this present research finding was to formulate mucoadhesive film for a water insoluble drug using different plasticizers and to study the effect of plasticizers in formulating buccal films. Buccal drug delivery is a safer and easier method of drug utilization. Methods: Buccal films were prepared by using Hydroxy Propyl Methyl Cellulose (HPMC) as the polymer and Glycerine, Propylene glycol, Dibutyl phthalate, Triethanolamine as plasticizers. Methanol and acetone were used as solvents. Prepared buccal films were evaluated in terms of surface pH, swelling index, folding endurance, film weight, film thickness and other parameters. Drug-polymer interaction was investigated through FT-IR spectroscopy. Percentage drug content was also determined. In-vitro drug release studies was carried out using open ended cylinder method in phosphate buffer of pH6.8. Results: Results showed that formulation F2 gave sustained drug release compare to other formulations. FT-IR studies did not showed any significant drug polymer interaction. Conclusion: It was concluded that buccal films prepared by using Propylene glycol as the plasticizer in the solvent methanol, promotes sustained drug release over a period of 6 hours of study and hence proves to be a good plasticizer in formulating buccal films which showed satisfactory results.